- Monologue jokes that included shots at NBC - "I'm going to be honest: It's not easy doing a late-night show on a channel without a lot of money and that viewers have trouble finding. So that's why I left NBC." - and even his new employer:
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- A new set that featured a full moon and an ocean view, the former of which Conan could move around with a remote control.
- Seth Rogen as a guest, talking about proposing to a topless Lauren Miller and joking that he placed the ring on her nipple.
- Lea Michele as another guest, saying of her scandalous GQ pictorial: "We were just having fun."
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